Tonic Inhibition
and Traumatic Brain Injury

The hippocampus provides a well known electrophysiological foundation to evaluate the effects of traumatic brain injury (TBI) on the inhibitory balance of a neuronal circuit. I evaluated tonic inhibitory currents and GABA induced inhibitory K+ currents after TBI. Assessing their acute and chronic changes, from the perspective of hyperactivity and hypersynchronization observed after TBI, I described impaired inhibitory imbalance in the hippocampal neuronal network.

A. Parga, A. F. Logsdon, W. A. Banks & C. Ransom (2021). Traumatic brain injury broadly affects GABAergic signaling in dentate gyrus granule cells. eNeuro